中文名 | Neuromedin B |
英文名 | Neuromedin B |
别名 | 神经介素 B 铃蟾肽相关肽 猪神经调节肽 B NEUROMEDIN B肽 化合物NEUROMEDIN B |
英文别名 | Neuromedin B NEUROMEDIN B GNLWATGHFM-NH2 NEUROMEDIN B, PORCINE NEUROMEDIN B (HUMAN, PORCINE, RAT) GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 NEUROMEDIN B (HUMAN, PORCINE, RAT) ACOH 5H2O H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O |
CAS | 87096-84-2 |
化学式 | C52H73N15O12S |
分子量 | 1132.29 |
存储条件 | −20°C |
MDL号 | MFCD00167607 |
体外研究 | Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC 50 ) is only 5% of BN (EC 50 of BN/EC 50 of NMB) and about 10% of GRP (EC 50 of GRP/ EC 50 of NMB). |
体内研究 | Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED 50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively. |
WGK Germany | 3 |
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